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On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability

Publication ,  Journal Article
Chen, KW; Papadopoulos, AS; Chow, SC
Published in: Communications in Statistics Part B: Simulation and Computation
January 1, 1997

Similar to Schuirmann's two one-sided tests procedure for assessment of bioequivalence in average bioavailability (Schuirmann, 1987), Liu and Chow (1992) proposed a two one-sided tests procedure for assessment of equivalence of variability of bioavailability. Their procedure is derived based on the correlation between crossover differences and subject totals. In this paper, we examined the performance of their test procedure in terms of its test size and power for various situations where the intersubject variability and the intrasubject variability of the test drug product are relatively larger, similar, and smaller than that of the intrasubject variability of the reference drug product.

Duke Scholars

Published In

Communications in Statistics Part B: Simulation and Computation

DOI

ISSN

0361-0918

Publication Date

January 1, 1997

Volume

26

Issue

3

Start / End Page

1129 / 1138

Related Subject Headings

  • Statistics & Probability
  • 49 Mathematical sciences
  • 46 Information and computing sciences
  • 08 Information and Computing Sciences
  • 01 Mathematical Sciences
 

Citation

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Chen, K. W., Papadopoulos, A. S., & Chow, S. C. (1997). On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability. Communications in Statistics Part B: Simulation and Computation, 26(3), 1129–1138. https://doi.org/10.1080/03610919708813430
Chen, K. W., A. S. Papadopoulos, and S. C. Chow. “On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability.” Communications in Statistics Part B: Simulation and Computation 26, no. 3 (January 1, 1997): 1129–38. https://doi.org/10.1080/03610919708813430.
Chen KW, Papadopoulos AS, Chow SC. On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability. Communications in Statistics Part B: Simulation and Computation. 1997 Jan 1;26(3):1129–38.
Chen, K. W., et al. “On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability.” Communications in Statistics Part B: Simulation and Computation, vol. 26, no. 3, Jan. 1997, pp. 1129–38. Scopus, doi:10.1080/03610919708813430.
Chen KW, Papadopoulos AS, Chow SC. On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability. Communications in Statistics Part B: Simulation and Computation. 1997 Jan 1;26(3):1129–1138.
Journal cover image

Published In

Communications in Statistics Part B: Simulation and Computation

DOI

ISSN

0361-0918

Publication Date

January 1, 1997

Volume

26

Issue

3

Start / End Page

1129 / 1138

Related Subject Headings

  • Statistics & Probability
  • 49 Mathematical sciences
  • 46 Information and computing sciences
  • 08 Information and Computing Sciences
  • 01 Mathematical Sciences