On the test of Liu and Chow's procedure for assessing equivalence in variability of bioavailability

Published

Journal Article

Similar to Schuirmann's two one-sided tests procedure for assessment of bioequivalence in average bioavailability (Schuirmann, 1987), Liu and Chow (1992) proposed a two one-sided tests procedure for assessment of equivalence of variability of bioavailability. Their procedure is derived based on the correlation between crossover differences and subject totals. In this paper, we examined the performance of their test procedure in terms of its test size and power for various situations where the intersubject variability and the intrasubject variability of the test drug product are relatively larger, similar, and smaller than that of the intrasubject variability of the reference drug product.

Full Text

Duke Authors

Cited Authors

  • Chen, KW; Papadopoulos, AS; Chow, SC

Published Date

  • January 1, 1997

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 1129 - 1138

International Standard Serial Number (ISSN)

  • 0361-0918

Digital Object Identifier (DOI)

  • 10.1080/03610919708813430

Citation Source

  • Scopus