Two-stage sampling in pharmaceutical applications.

Journal Article (Journal Article)

In the pharmaceutical industry, some tests for quality assurance before, during and after the manufacture of a drug product involve a two-stage sampling technique. We propose statistical testing procedures in a two-stage sampling problem with large within-class sample sizes. We also derive a two-stage sampling plan by minimizing the expected squared volume (or the generalized variance) of the confidence region related to the test. We present two examples to illustrate the proposed methods.

Full Text

Duke Authors

Cited Authors

  • Shao, J; Chow, SC

Published Date

  • November 15, 1993

Published In

Volume / Issue

  • 12 / 21

Start / End Page

  • 1999 - 2008

PubMed ID

  • 8296110

International Standard Serial Number (ISSN)

  • 0277-6715

Digital Object Identifier (DOI)

  • 10.1002/sim.4780122104

Language

  • eng

Conference Location

  • England