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Effect of oxygen at high pressure on spontaneous transmitter release

Publication ,  Journal Article
Colton, JS; Colton, CA
Published in: American Journal of Physiology - Cell Physiology
December 1, 1978

The effect of oxygen at high pressure (OHP) on resting membrane properties [effective membrane resistance (R(eff)) and membrane potential (V(m))] and the spontaneous release of excitatory transmitter were examined at the lobster neuromuscular junction. Pressurization with 100% oxygen to 150 pounds per square inch gauge pressure (psig) or with nitrogen to 150 psig (7,000 mmHg nitrogen and 135 mmHg oxygen) produced a decrease in R(eff) associated with a hyperpolarization of V(m). These changes, however, returned to control values within 20-30 min after completion of pressurization. Spontaneous release of excitatory transmitter was shown to increase dramatically in the presence of 100% oxygen at 150 psig. The increase in miniature end-plate potential (MEPP) frequency persisted beyond the transient changes seen with R(eff) and V(m). This effect was selective to oxygen, as pressurization with nitrogen did not produce an increase in MEPP frequency. No change in average MEPP amplitude was seen with either OHP or pressure alone. An OHP-induced increase in MEPP frequency was also seen at the frog neuromuscular junction. The results indicate that both glutamate-mediated and acetylcholine-mediated synaptic transmission are altered by OHP.

Duke Scholars

Published In

American Journal of Physiology - Cell Physiology

ISSN

0363-6143

Publication Date

December 1, 1978

Volume

4

Issue

3

Related Subject Headings

  • Physiology
  • 1116 Medical Physiology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Colton, J. S., & Colton, C. A. (1978). Effect of oxygen at high pressure on spontaneous transmitter release. American Journal of Physiology - Cell Physiology, 4(3).
Colton, J. S., and C. A. Colton. “Effect of oxygen at high pressure on spontaneous transmitter release.” American Journal of Physiology - Cell Physiology 4, no. 3 (December 1, 1978).
Colton JS, Colton CA. Effect of oxygen at high pressure on spontaneous transmitter release. American Journal of Physiology - Cell Physiology. 1978 Dec 1;4(3).
Colton, J. S., and C. A. Colton. “Effect of oxygen at high pressure on spontaneous transmitter release.” American Journal of Physiology - Cell Physiology, vol. 4, no. 3, Dec. 1978.
Colton JS, Colton CA. Effect of oxygen at high pressure on spontaneous transmitter release. American Journal of Physiology - Cell Physiology. 1978 Dec 1;4(3).

Published In

American Journal of Physiology - Cell Physiology

ISSN

0363-6143

Publication Date

December 1, 1978

Volume

4

Issue

3

Related Subject Headings

  • Physiology
  • 1116 Medical Physiology
  • 0606 Physiology
  • 0601 Biochemistry and Cell Biology