The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes

Journal Article (Journal Article)

We have prepared a series of dihydroxamates and their iron (III) complexes in view of obtaining new NMR imaging agents. Four new dihydroxamic acid ligands have been synthesized by condensation of 4-substituted-2,6-pyridine dicarboxylic acids with N-aminopropyl-N-acetylhydroxylamine, and the iron (III) complexes exhibit high stability over the pH range 3 to 7 and a binuclear structure Fe2L3 at pH7. The presence of two non-interacting paramagnetic centers per mole should allow a good compromise between an efficient relaxivity and limited toxicity. © 1990.

Full Text

Duke Authors

Cited Authors

  • Chaubet, F; van duong, MN; Gref, A; Courtieu, J; Crumbliss, AL; Gaudemer, A; M. Gross, P

Published Date

  • January 1, 1990

Published In

Volume / Issue

  • 31 / 40

Start / End Page

  • 5729 - 5732

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(00)97943-7

Citation Source

  • Scopus