Iron bioavailability and the coordination chemistry of hydroxamic acids

Journal Article (Journal Article)

The mechanism of iron bioavailability and the principles underlying siderophore affinity and specificity for iron are briefly reviewed. The kinetics and mechanism of iron dissociation from ferrioxamine B under conditions of low pH, or competing ligands, is discussed and compared with similar data for iron complexes with synthetic hydroxamic acids. Data are also presented for ferrioxamine B ligand exchange kinetics in the presence of surfactants. The mechanisms for the surfactant enhanced reactions are discussed and related to their possible relevance to iron dissociation from a hydroxamic acid siderophore complex at the cell surface. © 1990.

Full Text

Duke Authors

Cited Authors

  • Crumbliss, AL

Published Date

  • November 1, 1990

Published In

Volume / Issue

  • 105 / C

Start / End Page

  • 155 - 179

International Standard Serial Number (ISSN)

  • 0010-8545

Digital Object Identifier (DOI)

  • 10.1016/0010-8545(90)80021-K

Citation Source

  • Scopus