Hypothesis: is lung disease after silicate inhalation caused by oxidant generation?

Journal Article (Review;Journal Article)

Inhaled silicate dusts may cause lung disease through their surface coordination of iron with subsequent oxidant generation via the Fenton reaction. Pneumoconiosis, irritant bronchitis, focal emphysema, and carcinoma may be produced by oxidants either directly through lipid peroxidation and protein inactivation, or indirectly by oxidant-mediated release of cytokines such as platelet-derived growth factor. The increased incidence of tuberculosis observed among silicate workers could be explained by accumulation of iron complexed by dust particles in the lung and made available to dormant mycobacteria as a virulence factor.

Full Text

Duke Authors

Cited Authors

  • Ghio, AJ; Kennedy, TP; Schapira, RM; Crumbliss, AL; Hoidal, JR

Published Date

  • October 1990

Published In

Volume / Issue

  • 336 / 8721

Start / End Page

  • 967 - 969

PubMed ID

  • 1977006

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/0140-6736(90)92421-d


  • eng