Nitroaromatic stimulation of superoxide production in three species of freshwater fish
Journal Article
Nitroaromatic compounds frequently contaminate aquatic systems and may, therefore, impact fish. However, a known pathway of nitroaromatic toxicity in mammals, that of nitroaromatic stimulated superoxide (O2-) production, has yet to be addressed in fish. In this study we investigated this pathway in three species of freshwater fish-channel catfish (Ictalurus punctatus), largemouth bass (Micropterus salmoides) and rainbow trout (Salmo gairdneri)-exposed to nitrofurantoin (NF), p-nitrobenzoic acid (PNBA) and m-dinitrobenzene (MDNB). Our results indicate that these nitroaromatics elicit a stimulation of O2- production by fish liver fractions. Additionally, results suggests a similarity between, fish and mammals in the nitroreductases which mediate nitroaromatic activation and subsequent O2- production. These findings indicate a potential toxic consequence of fish exposure to nitroaromatic contaminants in aquatic systems. © 1988.
Full Text
Duke Authors
Cited Authors
- Washburn, PC; Di Giulio, RT
Published Date
- January 1, 1988
Published In
Volume / Issue
- 24 / 1-4
Start / End Page
- 291 - 294
International Standard Serial Number (ISSN)
- 0141-1136
Digital Object Identifier (DOI)
- 10.1016/0141-1136(88)90323-6
Citation Source
- Scopus