Nitroaromatic stimulation of superoxide production in three species of freshwater fish

Journal Article

Nitroaromatic compounds frequently contaminate aquatic systems and may, therefore, impact fish. However, a known pathway of nitroaromatic toxicity in mammals, that of nitroaromatic stimulated superoxide (O2-) production, has yet to be addressed in fish. In this study we investigated this pathway in three species of freshwater fish-channel catfish (Ictalurus punctatus), largemouth bass (Micropterus salmoides) and rainbow trout (Salmo gairdneri)-exposed to nitrofurantoin (NF), p-nitrobenzoic acid (PNBA) and m-dinitrobenzene (MDNB). Our results indicate that these nitroaromatics elicit a stimulation of O2- production by fish liver fractions. Additionally, results suggests a similarity between, fish and mammals in the nitroreductases which mediate nitroaromatic activation and subsequent O2- production. These findings indicate a potential toxic consequence of fish exposure to nitroaromatic contaminants in aquatic systems. © 1988.

Full Text

Duke Authors

Cited Authors

  • Washburn, PC; Di Giulio, RT

Published Date

  • January 1, 1988

Published In

Volume / Issue

  • 24 / 1-4

Start / End Page

  • 291 - 294

International Standard Serial Number (ISSN)

  • 0141-1136

Digital Object Identifier (DOI)

  • 10.1016/0141-1136(88)90323-6

Citation Source

  • Scopus