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Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia

Publication ,  Journal Article
Lopez, JJ; Edelman, ER; Stamler, A; Hibberd, MG; Prasad, P; Thomas, KA; DiSalvo, J; Caputo, RP; Carrozza, JP; Douglas, PS; Sellke, FW; Simons, M
Published in: American Journal of Physiology - Heart and Circulatory Physiology
March 1, 1998

A number of heparin-binding growth factors, including basic (bFGF) and acidic (aFGF) fibroblast growth factors have been shown to promote angiogenesis in vivo. In this study, we employed a sustained-release polymer extravascular delivery system to evaluate the angiogenic efficacy of a novel form of genetically modified aFGF in the setting of chronic myocardial ischemia. Fifteen Yorkshire pigs subjected to Ameroid occluder placement on the left circumflex (LCX) artery were treated with perivascularly administered aFGF in ethylene vinyl acetate (EVAc) polymer (10 μg, n = 7) or EVAc alone (controls, n = 8). Seven to nine weeks later, after coronary angiography to document Ameroid-induced coronary occlusion, all animals underwent studies of coronary now and global and regional left ventricular function. Microsphere-determined coronary flow in the Ameroid-compromised territory was significantly increased in aFGF-treated compared with control animals, and this improvement in perfusion was maintained during ventricular pacing. Left ventricular function studies demonstrated improved global and regional function in aFGF-treated animals. We conclude that local perivascular delivery of genetically modified aFGF results in significant improvement in myocardial flow and regional and global left ventricular function. Copyright © 1998 the American Physiological Society.

Duke Scholars

Published In

American Journal of Physiology - Heart and Circulatory Physiology

ISSN

0363-6135

Publication Date

March 1, 1998

Volume

43

Issue

3

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology
 

Citation

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Lopez, J. J., Edelman, E. R., Stamler, A., Hibberd, M. G., Prasad, P., Thomas, K. A., … Simons, M. (1998). Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. American Journal of Physiology - Heart and Circulatory Physiology, 43(3).
Lopez, J. J., E. R. Edelman, A. Stamler, M. G. Hibberd, P. Prasad, K. A. Thomas, J. DiSalvo, et al. “Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia.” American Journal of Physiology - Heart and Circulatory Physiology 43, no. 3 (March 1, 1998).
Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Thomas KA, et al. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. American Journal of Physiology - Heart and Circulatory Physiology. 1998 Mar 1;43(3).
Lopez, J. J., et al. “Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia.” American Journal of Physiology - Heart and Circulatory Physiology, vol. 43, no. 3, Mar. 1998.
Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Thomas KA, DiSalvo J, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. American Journal of Physiology - Heart and Circulatory Physiology. 1998 Mar 1;43(3).

Published In

American Journal of Physiology - Heart and Circulatory Physiology

ISSN

0363-6135

Publication Date

March 1, 1998

Volume

43

Issue

3

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology