Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia.
Journal Article (Journal Article)
A number of heparin-binding growth factors, including basic (bFGF) and acidic (aFGF) fibroblast growth factors have been shown to promote angiogenesis in vivo. In this study, we employed a sustained-release polymer extravascular delivery system to evaluate the angiogenic efficacy of a novel form of genetically modified aFGF in the setting of chronic myocardial ischemia. Fifteen Yorkshire pigs subjected to Ameroid occluder placement on the left circumflex (LCX) artery were treated with perivascularly administered aFGF in ethylene vinyl acetate (EVAc) polymer (10 micrograms, n = 7) or EVAc alone (controls, n = 8). Seven to nine weeks later, after coronary angiography to document Ameroid-induced coronary occlusion, all animals underwent studies of coronary flow and global and regional left ventricular function. Microsphere-determined coronary flow in the Ameroid-compromised territory was significantly increased in aFGF-treated compared with control animals, and this improvement in perfusion was maintained during ventricular pacing. Left ventricular function studies demonstrated improved global and regional function in aFGF-treated animals. We conclude that local perivascular delivery of genetically modified aFGF results in significant improvement in myocardial flow and regional and global left ventricular function.
Full Text
Duke Authors
Cited Authors
- Lopez, JJ; Edelman, ER; Stamler, A; Hibberd, MG; Prasad, P; Thomas, KA; DiSalvo, J; Caputo, RP; Carrozza, JP; Douglas, PS; Sellke, FW; Simons, M
Published Date
- March 1, 1998
Published In
Volume / Issue
- 274 / 3
Start / End Page
- H930 - H936
PubMed ID
- 9530206
International Standard Serial Number (ISSN)
- 0002-9513
Digital Object Identifier (DOI)
- 10.1152/ajpheart.1998.274.3.H930
Language
- eng
Conference Location
- United States