Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia.

Published

Journal Article

A number of heparin-binding growth factors, including basic (bFGF) and acidic (aFGF) fibroblast growth factors have been shown to promote angiogenesis in vivo. In this study, we employed a sustained-release polymer extravascular delivery system to evaluate the angiogenic efficacy of a novel form of genetically modified aFGF in the setting of chronic myocardial ischemia. Fifteen Yorkshire pigs subjected to Ameroid occluder placement on the left circumflex (LCX) artery were treated with perivascularly administered aFGF in ethylene vinyl acetate (EVAc) polymer (10 micrograms, n = 7) or EVAc alone (controls, n = 8). Seven to nine weeks later, after coronary angiography to document Ameroid-induced coronary occlusion, all animals underwent studies of coronary flow and global and regional left ventricular function. Microsphere-determined coronary flow in the Ameroid-compromised territory was significantly increased in aFGF-treated compared with control animals, and this improvement in perfusion was maintained during ventricular pacing. Left ventricular function studies demonstrated improved global and regional function in aFGF-treated animals. We conclude that local perivascular delivery of genetically modified aFGF results in significant improvement in myocardial flow and regional and global left ventricular function.

Full Text

Duke Authors

Cited Authors

  • Lopez, JJ; Edelman, ER; Stamler, A; Hibberd, MG; Prasad, P; Thomas, KA; DiSalvo, J; Caputo, RP; Carrozza, JP; Douglas, PS; Sellke, FW; Simons, M

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 274 / 3

Start / End Page

  • H930 - H936

PubMed ID

  • 9530206

Pubmed Central ID

  • 9530206

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.1998.274.3.H930

Language

  • eng

Conference Location

  • United States