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Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters.

Publication ,  Journal Article
Lopez, JJ; Edelman, ER; Stamler, A; Hibberd, MG; Prasad, P; Caputo, RP; Carrozza, JP; Douglas, PS; Sellke, FW; Simons, M
Published in: J Pharmacol Exp Ther
July 1997

Recently, a number of growth factors including basic fibroblast growth factor (bFGF) have been shown to promote angiogenesis in vivo. In this study, we evaluated dose-dependent effect of bFGF administration in the setting of chronic myocardial ischemia. A total of 18 Yorkshire pigs subjected to ameroid occluder placement on the left circumflex artery were randomized to treatment with 10 (n = 6) or 100 microg (n = 5) of bFGF incorporated into heparin-alginate microspheres or inactive control pellets (n = 7). Eight weeks later, all animals underwent angiographic evaluation of collateral development as well as studies of coronary flow and global and regional left ventricular function. Both bFGF groups had significantly higher angiographic collateral index, TIMI flow scores and coronary flow in the ameroid-compromised territory compared with controls. Left ventricular function studies demonstrated improved global and regional function in both fibroblast growth factor groups with significantly better preservation of regional wall motion in high dose (100 microg) bFGF animals. We conclude that local perivascular delivery of bFGF results in significant improvement in myocardial function in the setting of chronic myocardial ischemia.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

July 1997

Volume

282

Issue

1

Start / End Page

385 / 390

Location

United States

Related Subject Headings

  • Swine
  • Pharmacology & Pharmacy
  • Myocardial Ischemia
  • Fibroblast Growth Factor 2
  • Echocardiography
  • Dose-Response Relationship, Drug
  • Coronary Circulation
  • Coronary Angiography
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Lopez, J. J., Edelman, E. R., Stamler, A., Hibberd, M. G., Prasad, P., Caputo, R. P., … Simons, M. (1997). Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J Pharmacol Exp Ther, 282(1), 385–390.
Lopez, J. J., E. R. Edelman, A. Stamler, M. G. Hibberd, P. Prasad, R. P. Caputo, J. P. Carrozza, P. S. Douglas, F. W. Sellke, and M. Simons. “Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters.J Pharmacol Exp Ther 282, no. 1 (July 1997): 385–90.
Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Caputo RP, et al. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J Pharmacol Exp Ther. 1997 Jul;282(1):385–90.
Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J Pharmacol Exp Ther. 1997 Jul;282(1):385–390.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

July 1997

Volume

282

Issue

1

Start / End Page

385 / 390

Location

United States

Related Subject Headings

  • Swine
  • Pharmacology & Pharmacy
  • Myocardial Ischemia
  • Fibroblast Growth Factor 2
  • Echocardiography
  • Dose-Response Relationship, Drug
  • Coronary Circulation
  • Coronary Angiography
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences