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Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.

Publication ,  Journal Article
Eysmann, SB; Palevsky, HI; Reichek, N; Hackney, K; Douglas, PS
Published in: Circulation
August 1989

To determine correlates of survival in primary pulmonary hypertension, we compared 41 echocardiography-Doppler and nine catheterization parameters with outcome in 26 patients. Mean follow-up was 19.7 months in survivors; mean survival was 4.8 months in 16 nonsurvivors. Cox life-table univariate analysis correlated two echocardiographic, three Doppler, and three catheterization variables with poor survival (p less than or equal to 0.05), and chi 2 analysis ensured the best critical values: severity of pericardial effusion, heart rate of more than 87 beats/min, pulmonic flow acceleration time of less than 62 msec, tricuspid early flow deceleration (T-DEC) equal to or less than -300 cm2/sec, mitral early flow-to-atrial flow velocity ratio (M-E/A) equal to or less than 1.0, catheterization cardiac index (CI) equal to or less than 2.3 l/min/m2, mean pulmonary artery pressure of more than 61 mm Hg, and diastolic pulmonary artery pressure of more than 43 mm Hg. Multivariate life-table analysis of noninvasive variables revealed the severity of pericardial effusion to be independently significant (p = 0.006), whereas analysis of catheterization variables revealed cardiac index to be independently significant (p = 0.014). Combined multivariate analysis did not differ from the noninvasive results alone. Categorical modeling of the eight significant variables split at their critical values (present or absent) revealed M-E/A, T-DEC, and CI to be independently significant by multivariate analysis (p = 0.0014). Analysis of the five echocardiography-Doppler variables alone revealed M-E/A, T-DEC, and heart rate to be independently significant (p = 0.0016). In both cases, mortality increased with the number of critical values reached.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

August 1989

Volume

80

Issue

2

Start / End Page

353 / 360

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Prognosis
  • Models, Cardiovascular
  • Male
  • Hypertension, Pulmonary
  • Humans
  • Female
  • Echocardiography, Doppler
  • Echocardiography
  • Cardiovascular System & Hematology
 

Citation

APA
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Eysmann, S. B., Palevsky, H. I., Reichek, N., Hackney, K., & Douglas, P. S. (1989). Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension. Circulation, 80(2), 353–360. https://doi.org/10.1161/01.cir.80.2.353
Eysmann, S. B., H. I. Palevsky, N. Reichek, K. Hackney, and P. S. Douglas. “Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.Circulation 80, no. 2 (August 1989): 353–60. https://doi.org/10.1161/01.cir.80.2.353.
Eysmann SB, Palevsky HI, Reichek N, Hackney K, Douglas PS. Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension. Circulation. 1989 Aug;80(2):353–60.
Eysmann, S. B., et al. “Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.Circulation, vol. 80, no. 2, Aug. 1989, pp. 353–60. Pubmed, doi:10.1161/01.cir.80.2.353.
Eysmann SB, Palevsky HI, Reichek N, Hackney K, Douglas PS. Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension. Circulation. 1989 Aug;80(2):353–360.

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

August 1989

Volume

80

Issue

2

Start / End Page

353 / 360

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Prognosis
  • Models, Cardiovascular
  • Male
  • Hypertension, Pulmonary
  • Humans
  • Female
  • Echocardiography, Doppler
  • Echocardiography
  • Cardiovascular System & Hematology