A biometrical genome search in rats reveals the multigenic basis of blood pressure variation.

Published

Journal Article

A genome-wide search for multiple loci influencing salt-loaded systolic blood pressure (NaSBP) variation among 188 F2 progeny from a cross between the Brown-Norway and spontaneously hypertensive rat strains was pursued in an effort to gain insight into the polygenic basis of blood pressure regulation. The results suggest that loci within five to six genomic regions collectively explain approximately 43% of the total NaSBP variation exhibited among the 188 F2 progeny. Many of these loci are in regions that previous studies have not implicated in blood pressure regulation. Ultimately, however, this study not only sheds light on the multigenic basis of blood pressure but provides further evidence that the identification of the genetic determinants of polygenic traits in mammals is possible with modern biometrical and molecular genetic tools in controlled settings (i.e., breeding paradigm and model organism).

Full Text

Duke Authors

Cited Authors

  • Schork, NJ; Krieger, JE; Trolliet, MR; Franchini, KG; Koike, G; Krieger, EM; Lander, ES; Dzau, VJ; Jacob, HJ

Published Date

  • September 1995

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 164 - 172

PubMed ID

  • 9132270

Pubmed Central ID

  • 9132270

International Standard Serial Number (ISSN)

  • 1088-9051

Digital Object Identifier (DOI)

  • 10.1101/gr.5.2.164

Language

  • eng

Conference Location

  • United States