A genetic linkage map of the laboratory rat, Rattus norvegicus.

Journal Article

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR x BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.

Full Text

Duke Authors

Cited Authors

  • Jacob, HJ; Brown, DM; Bunker, RK; Daly, MJ; Dzau, VJ; Goodman, A; Koike, G; Kren, V; Kurtz, T; Lernmark, A

Published Date

  • January 1995

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 63 - 69

PubMed ID

  • 7704027

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng0195-63

Language

  • eng

Conference Location

  • United States