Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.

Published

Journal Article

The renin-angiotensin system plays an important role in blood pressure homeostasis, but the contribution of the type 2 angiotensin II receptor (AT2R) is still unclear. The reports that the AT2R gene has been mapped to the X chromosome in human and rat and the previous report of a gene, Bp3, on the X chromosome responsible for an increase in blood pressure have suggested that the rat AT2R gene (Agtr2) could be this gene. To elucidate whether Agtr2 is Bp3, Agtr2 was cloned. A simple sequence repeat in the 3'-flanking region of this gene was identified and used as a genetic marker to map Agtr2 to the X chromosome at 18.1 cM distal to the androgen receptor locus. This map position is outside the confidence interval reported for Bp3, demonstrating that Agtr2 cannot be Bp3. However, these data will enhance the research into the AT2R biology as well as the study of the X chromosome.

Full Text

Duke Authors

Cited Authors

  • Koike, G; Winer, ES; Horiuchi, M; Brown, DM; Szpirer, C; Dzau, VJ; Jacob, HJ

Published Date

  • December 1995

Published In

Volume / Issue

  • 26 / 6 Pt 1

Start / End Page

  • 998 - 1002

PubMed ID

  • 7490161

Pubmed Central ID

  • 7490161

International Standard Serial Number (ISSN)

  • 0194-911X

Language

  • eng

Conference Location

  • United States