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Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.

Publication ,  Journal Article
Hein, L; Dzau, VJ; Barsh, GS
Published in: Genomics
November 20, 1995

Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

November 20, 1995

Volume

30

Issue

2

Start / End Page

369 / 371

Location

United States

Related Subject Headings

  • X Chromosome
  • Receptors, Angiotensin
  • Primary Ovarian Insufficiency
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice
  • Humans
  • Genetics & Heredity
  • Genetic Linkage
  • Female
 

Citation

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ICMJE
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Hein, L., Dzau, V. J., & Barsh, G. S. (1995). Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome. Genomics, 30(2), 369–371. https://doi.org/10.1006/geno.1995.0033
Hein, L., V. J. Dzau, and G. S. Barsh. “Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.Genomics 30, no. 2 (November 20, 1995): 369–71. https://doi.org/10.1006/geno.1995.0033.
Hein L, Dzau VJ, Barsh GS. Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome. Genomics. 1995 Nov 20;30(2):369–71.
Hein, L., et al. “Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.Genomics, vol. 30, no. 2, Nov. 1995, pp. 369–71. Pubmed, doi:10.1006/geno.1995.0033.
Hein L, Dzau VJ, Barsh GS. Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome. Genomics. 1995 Nov 20;30(2):369–371.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

November 20, 1995

Volume

30

Issue

2

Start / End Page

369 / 371

Location

United States

Related Subject Headings

  • X Chromosome
  • Receptors, Angiotensin
  • Primary Ovarian Insufficiency
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice
  • Humans
  • Genetics & Heredity
  • Genetic Linkage
  • Female