Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.

Journal Article

Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt.

Full Text

Duke Authors

Cited Authors

  • Hein, L; Dzau, VJ; Barsh, GS

Published Date

  • November 20, 1995

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 369 - 371

PubMed ID

  • 8586443

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1995.0033

Language

  • eng

Conference Location

  • United States