Desensitization of angiotensin receptor function.
Angiotensin II is an eight amino acid peptide which plays a major role in the regulation of cardiovascular homeostasis. The physiologic effects of angiotensin (Ang) II are mediated by a G-protein coupled receptor, termed AT1, which activates phospholipase C. A major factor regulating angiotensin II receptor function is the rapid desensitization following agonist stimulation. However, despite years of investigation, the mechanism by which the angiotensin receptor is regulated remains unclear. The cloning of the AT-1 receptor and the availability of cell lines which stabily express this receptor has helped elucidate these mechanisms. In this paper, we review the data from our laboratory concerning the post-translational regulation of the angiotensin receptor function.
Duke Scholars
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Related Subject Headings
- Urology & Nephrology
- Transfection
- Signal Transduction
- Receptors, Angiotensin
- Mice
- Humans
- Cloning, Molecular
- Cell Line
- Animals
- 3202 Clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Urology & Nephrology
- Transfection
- Signal Transduction
- Receptors, Angiotensin
- Mice
- Humans
- Cloning, Molecular
- Cell Line
- Animals
- 3202 Clinical sciences