Desensitization of angiotensin receptor function.


Journal Article (Review)

Angiotensin II is an eight amino acid peptide which plays a major role in the regulation of cardiovascular homeostasis. The physiologic effects of angiotensin (Ang) II are mediated by a G-protein coupled receptor, termed AT1, which activates phospholipase C. A major factor regulating angiotensin II receptor function is the rapid desensitization following agonist stimulation. However, despite years of investigation, the mechanism by which the angiotensin receptor is regulated remains unclear. The cloning of the AT-1 receptor and the availability of cell lines which stabily express this receptor has helped elucidate these mechanisms. In this paper, we review the data from our laboratory concerning the post-translational regulation of the angiotensin receptor function.

Full Text

Duke Authors

Cited Authors

  • Sasamura, H; Dzau, VJ; Pratt, RE

Published Date

  • December 1994

Published In

Volume / Issue

  • 46 / 6

Start / End Page

  • 1499 - 1501

PubMed ID

  • 7699989

Pubmed Central ID

  • 7699989

International Standard Serial Number (ISSN)

  • 0085-2538

Digital Object Identifier (DOI)

  • 10.1038/ki.1994.429


  • eng

Conference Location

  • United States