Desensitization of angiotensin receptor function.
Published
Journal Article (Review)
Angiotensin II is an eight amino acid peptide which plays a major role in the regulation of cardiovascular homeostasis. The physiologic effects of angiotensin (Ang) II are mediated by a G-protein coupled receptor, termed AT1, which activates phospholipase C. A major factor regulating angiotensin II receptor function is the rapid desensitization following agonist stimulation. However, despite years of investigation, the mechanism by which the angiotensin receptor is regulated remains unclear. The cloning of the AT-1 receptor and the availability of cell lines which stabily express this receptor has helped elucidate these mechanisms. In this paper, we review the data from our laboratory concerning the post-translational regulation of the angiotensin receptor function.
Full Text
Duke Authors
Cited Authors
- Sasamura, H; Dzau, VJ; Pratt, RE
Published Date
- December 1994
Published In
Volume / Issue
- 46 / 6
Start / End Page
- 1499 - 1501
PubMed ID
- 7699989
Pubmed Central ID
- 7699989
International Standard Serial Number (ISSN)
- 0085-2538
Digital Object Identifier (DOI)
- 10.1038/ki.1994.429
Language
- eng
Conference Location
- United States