Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.
Journal Article (Journal Article)
The human type 2 angiotensin II receptor (AT2R) gene was isolated from a human genomic DNA library of adult female leukocytes. The putative coding region of the human AT2R gene is intronless. The primary structure of the human AT2R deduced from the nucleotide sequence of this putative coding region contains 363 amino acid residues and is highly homologous to the sequences of the rat and mouse AT2R. The human AT2R gene was mapped to the X chromosome using chromosomal assignment analysis with a human/rodent somatic cell hybrid panel. Northern blot analysis demonstrated a 3.0 kb mRNA in the human fetal lung and kidney and the human adult lung. These data and probes should enhance research in human AT2R biology.
Full Text
Duke Authors
Cited Authors
- Koike, G; Horiuchi, M; Yamada, T; Szpirer, C; Jacob, HJ; Dzau, VJ
Published Date
- September 30, 1994
Published In
Volume / Issue
- 203 / 3
Start / End Page
- 1842 - 1850
PubMed ID
- 7945336
International Standard Serial Number (ISSN)
- 0006-291X
Digital Object Identifier (DOI)
- 10.1006/bbrc.1994.2402
Language
- eng
Conference Location
- United States