Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

Published

Journal Article

The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals.

Full Text

Duke Authors

Cited Authors

  • Jacob, HJ; Lindpaintner, K; Lincoln, SE; Kusumi, K; Bunker, RK; Mao, YP; Ganten, D; Dzau, VJ; Lander, ES

Published Date

  • October 1991

Published In

Volume / Issue

  • 67 / 1

Start / End Page

  • 213 - 224

PubMed ID

  • 1655275

Pubmed Central ID

  • 1655275

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(91)90584-l

Language

  • eng