Cardiac renin-angiotensin system. Molecular and functional aspects.

Published

Journal Article

Current data support the existence of an endogenous renin-angiotensin system in the heart. Vascular angiotensin may contribute to the regulation of coronary vascular tone. Enhanced local angiotensin production in areas of vascular injury or inflammation may result in increased vasoconstriction or vasospasm. Cardiac angiotensin may adversely influence myocardial metabolism and provoke ventricular arrhythmia during ischemia and reperfusion-induced myocardial injury. Local angiotensin may stimulate cardiac contractility. In addition, angiotensin may influence cardiac myocyte growth and may contribute to the development of cardiac hypertrophy in hypertension. Recent data show that the pharmacologic inhibition of cardiac angiotensin converting enzyme may have important therapeutic consequences for the ischemic, hypertrophic, or failing heart.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ

Published Date

  • March 11, 1988

Published In

Volume / Issue

  • 84 / 3A

Start / End Page

  • 22 - 27

PubMed ID

  • 3218653

Pubmed Central ID

  • 3218653

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(88)90201-x

Language

  • eng

Conference Location

  • United States