Cardiac renin-angiotensin system. Molecular and functional aspects.
Journal Article (Journal Article)
Current data support the existence of an endogenous renin-angiotensin system in the heart. Vascular angiotensin may contribute to the regulation of coronary vascular tone. Enhanced local angiotensin production in areas of vascular injury or inflammation may result in increased vasoconstriction or vasospasm. Cardiac angiotensin may adversely influence myocardial metabolism and provoke ventricular arrhythmia during ischemia and reperfusion-induced myocardial injury. Local angiotensin may stimulate cardiac contractility. In addition, angiotensin may influence cardiac myocyte growth and may contribute to the development of cardiac hypertrophy in hypertension. Recent data show that the pharmacologic inhibition of cardiac angiotensin converting enzyme may have important therapeutic consequences for the ischemic, hypertrophic, or failing heart.
Full Text
Duke Authors
Cited Authors
- Dzau, VJ
Published Date
- March 11, 1988
Published In
Volume / Issue
- 84 / 3A
Start / End Page
- 22 - 27
PubMed ID
- 3218653
International Standard Serial Number (ISSN)
- 0002-9343
Digital Object Identifier (DOI)
- 10.1016/0002-9343(88)90201-x
Language
- eng
Conference Location
- United States