Molecular biology of the renin-angiotensin system.

Journal Article (Journal Article;Review)

This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have important physiological functions, is also described. In addition, the pathway of renin biosynthesis and secretion is reviewed. This includes speculation on the fate of circulating prorenin and the physiological role of multiple renin forms and secretory pathways. The molecular approaches described in this paper have greatly advanced our knowledge of the biology of the renin-angiotensin system. Future studies using these and other approaches should provide further insight into this complex system.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ; Burt, DW; Pratt, RE

Published Date

  • October 1988

Published In

Volume / Issue

  • 255 / 4 Pt 2

Start / End Page

  • F563 - F573

PubMed ID

  • 3052109

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajprenal.1988.255.4.F563


  • eng

Conference Location

  • United States