Compensatory response to hemorrhage in conscious dogs on normal and low salt intake.

Published

Journal Article

The compensatory response to moderately severe hemorrhage (30 ml/kg) was studied in chronically catheterized conscious dogs maintained on normal and low salt intake. Although the fall in blood pressure and the increase in heart rate were similar in the two salt states, the salt-restricted animals had significantly greater rises in plasma renin activity and plasma catecholamines following hemorrhage than did the normal salt dogs. To compare further the relative roles of the alpha-adrenergic system and the renin-angiotensin system in the maintenance of blood pressure following hemorrhage, pharmacologic blockade with either phentolamine or converting enzyme inhibitor was performed 20 min after the completion of the hemorrhage. These latter experiments demonstrated that salt restriction resulted in a significantly greater role for the renin-angiotensin system. Moreover, interruption of the renin-angiotensin system blunted the anticipated rise in catecholamines and heart rate during the additional hypotension induced by converting enzyme blockade after hemorrhage.

Full Text

Duke Authors

Cited Authors

  • Kopelman, RI; Dzau, VJ; Shimabukuro, S; Barger, AC

Published Date

  • March 1983

Published In

Volume / Issue

  • 244 / 3

Start / End Page

  • H351 - H356

PubMed ID

  • 6187227

Pubmed Central ID

  • 6187227

Electronic International Standard Serial Number (EISSN)

  • 2163-5773

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.1983.244.3.h351

Language

  • eng