Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody.

Published

Journal Article

1. The major angiotensin I-generating activity of rat brain extracts has a pH optimum different from that of renal renin and is not inhibited by renin specific antibody. 2. Affinity chromatography utilizing renin specific antibody, pepstatin and alpha-casein yielded fractions that resembled renal renin more closely with respect to antibody inhibition and pH optimum as well as an absence of the ability to hydrolyse haemoglobin. 3. We conclude that rat brain contains a host of enzymes with angiotensin I-generating activity including acid and neutral proteases and an enzyme with the immunochemical identity of renal renin. The biosynthetic origins of this renin-like protein remain uncertain.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ; Brenner, A; Emmett, N; Haber, E

Published Date

  • December 1, 1980

Published In

Volume / Issue

  • 59 Suppl 6 /

Start / End Page

  • 45s - 47s

PubMed ID

  • 7004734

Pubmed Central ID

  • 7004734

International Standard Serial Number (ISSN)

  • 0143-5221

Language

  • eng

Conference Location

  • England