Dissimilar courses of twins with leukemia.

Journal Article (Journal Article)

Twin girls, genetically identical, probably experienced different leukemogenic events and presented with acute lymphocytic leukemia 6 years apart. Their clinical presentations were similar, but they received significantly different therapy. The first twin died 34 months after diagnosis following multiple remissions and relapses, having received single-drug maintenance. The second twin remains free of apparent disease 60 months after diagnosis, following vincristine and prednisone induction, 6-mercaptopurine maintenance, methotrexate and prednisone reinforcement, and central nervous system treatment of occult disease. Their dissimilar clinical courses may have been due to different leukemogenic events and/or markedly different therapeutic programs.

Full Text

Duke Authors

Cited Authors

  • Stewart, SJ; Shepherd, DA; Steuber, CP; Starling, KA; Falletta, JM

Published Date

  • 1977

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 231 - 235

PubMed ID

  • 284166

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950030303


  • eng

Conference Location

  • United States