Genetically controlled total deficiency of the fourth component of complement in the guinea pig.


Journal Article

Guinea pigs with a total deficiency of the fourth component of complement (C4) have been discovered. There was no evidence for the presence of a C4 inhibitor in the serum of these animals. Mating studies indicate that C4 deficiency is transmitted as a simple autosomal recessive trait. A colony of these animals is being established at the National Institutes of Health. They will provide an opportunity to more precisely define the role of complement in immune phenomena and the defense against disease.

Full Text

Cited Authors

  • Ellman, L; Green, I; Frank, M

Published Date

  • October 2, 1970

Published In

Volume / Issue

  • 170 / 3953

Start / End Page

  • 74 - 75

PubMed ID

  • 4989151

Pubmed Central ID

  • 4989151

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.170.3953.74


  • eng

Conference Location

  • United States