Anatomic applications of xenon-enhanced CT scanning: visual image analysis and brain-blood partition coefficient studies in man.

Journal Article (Journal Article)

The inhalation of nonradioactive xenon, an inert gas that diffuses freely across the blood-brain barrier, resulted in brain enhancement which was quantitated and visualized by computed tomography (CT). Serial CT scans obtained during the buildup and equilibrium phase of xenon inhalation were used in a numerical and visual analysis of xenon accumulation in multiple selected gray- and white-matter regions in 12 patients. The calculated brain-blood partition coefficient (lambda) in normal gray matter was 0.92 +/- 0.11 and in normal white matter, 1.38 +/- 0.14. Asymmetries and delays in xenon enhancement were often visually apparent. The estimated partition coefficient was diminished more with cerebral infarction, intracerebral hematoma, and vasogenic edema than with hypoxic encephalopathy or glioblastoma multiforme. An increase in the rate of xenon accumulation was apparent by visual inspection of the motor cortex contralateral to complex hand movements. Technical factors and potential difficulties in conducting xenon-enhanced CT studies are discussed.

Full Text

Duke Authors

Cited Authors

  • Drayer, BP; Friedman, A; Osborne, D; Albright, R; Bates, M

Published Date

  • 1983

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 577 - 582

PubMed ID

  • 6410801

Pubmed Central ID

  • PMC8335027

International Standard Serial Number (ISSN)

  • 0195-6108


  • eng

Conference Location

  • United States