Prevalence of rate-dependent behaviors in cardiac muscle


Journal Article

We explore the rate-dependent dynamic response of periodically paced bullfrog (Rana catesbeiana) cardiac muscle. Alternans (2:2 behavior) occur in 35% of animals and 2:1<-->1:1 bistability in 74% of animals. In addition, we observe 2:2<-->2:1 bistablility. We discuss the implications of these results for two map-based models of cardiac dynamics. The high prevalence of bistability suggests that this dynamical behavior must be accounted for in the design of closed-loop feedback protocols to stabilize cardiac dynamics. © 1999 The American Physical Society.

Full Text

Cited Authors

  • Martin, HG; Sonya, B; Gauthier, DJ

Published Date

  • January 1, 1999

Published In

Volume / Issue

  • 82 / 14

Start / End Page

  • 2995 - 2998

Electronic International Standard Serial Number (EISSN)

  • 1079-7114

International Standard Serial Number (ISSN)

  • 0031-9007

Digital Object Identifier (DOI)

  • 10.1103/PhysRevLett.82.2995

Citation Source

  • Scopus