Hereditary thrombotic thrombocytopenic purpura: microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurring in consecutive generations.

Journal Article (Journal Article)

Microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurred in a mother an daughter when each was in her third decade. The mother had prominent neurological findings, fever, and expired from renal insufficiency. Her daughter's only major symptom was renal insufficiency. The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants of a single clinical disorder, while their occurrence in direct descendents strengthens the postulate that in selected instances a genetic predisposition to these disorders may be important.

Full Text

Duke Authors

Cited Authors

  • Kirchner, KA; Smith, RM; Gockerman, JP; Luke, RG

Published Date

  • 1982

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 28 - 30

PubMed ID

  • 7201082

International Standard Serial Number (ISSN)

  • 1660-8151

Digital Object Identifier (DOI)

  • 10.1159/000182427


  • eng

Conference Location

  • Switzerland