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Hereditary thrombotic thrombocytopenic purpura: microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurring in consecutive generations.

Publication ,  Journal Article
Kirchner, KA; Smith, RM; Gockerman, JP; Luke, RG
Published in: Nephron
1982

Microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurred in a mother an daughter when each was in her third decade. The mother had prominent neurological findings, fever, and expired from renal insufficiency. Her daughter's only major symptom was renal insufficiency. The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants of a single clinical disorder, while their occurrence in direct descendents strengthens the postulate that in selected instances a genetic predisposition to these disorders may be important.

Duke Scholars

Published In

Nephron

DOI

ISSN

1660-8151

Publication Date

1982

Volume

30

Issue

1

Start / End Page

28 / 30

Location

Switzerland

Related Subject Headings

  • Urology & Nephrology
  • Thrombocytopenia
  • Renal Dialysis
  • Purpura, Thrombotic Thrombocytopenic
  • Kidney Failure, Chronic
  • Humans
  • Female
  • Anemia, Hemolytic
  • Adult
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Journal cover image

Published In

Nephron

DOI

ISSN

1660-8151

Publication Date

1982

Volume

30

Issue

1

Start / End Page

28 / 30

Location

Switzerland

Related Subject Headings

  • Urology & Nephrology
  • Thrombocytopenia
  • Renal Dialysis
  • Purpura, Thrombotic Thrombocytopenic
  • Kidney Failure, Chronic
  • Humans
  • Female
  • Anemia, Hemolytic
  • Adult
  • 3202 Clinical sciences