RBC transfusions in paroxysmal nocturnal hemoglobinuria.
Publication
, Journal Article
Gockerman, JP; Brouillard, RP
Published in: Arch Intern Med
April 1977
Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCS, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.
Duke Scholars
Published In
Arch Intern Med
ISSN
0003-9926
Publication Date
April 1977
Volume
137
Issue
4
Start / End Page
536 / 538
Location
United States
Related Subject Headings
- Vascular Surgical Procedures
- Middle Aged
- Male
- Humans
- Hemolysis
- Hemoglobinuria, Paroxysmal
- General & Internal Medicine
- Erythropoiesis
- Erythrocyte Transfusion
- Erythrocyte Membrane
Citation
APA
Chicago
ICMJE
MLA
NLM
Gockerman, J. P., & Brouillard, R. P. (1977). RBC transfusions in paroxysmal nocturnal hemoglobinuria. Arch Intern Med, 137(4), 536–538.
Gockerman, J. P., and R. P. Brouillard. “RBC transfusions in paroxysmal nocturnal hemoglobinuria.” Arch Intern Med 137, no. 4 (April 1977): 536–38.
Gockerman JP, Brouillard RP. RBC transfusions in paroxysmal nocturnal hemoglobinuria. Arch Intern Med. 1977 Apr;137(4):536–8.
Gockerman, J. P., and R. P. Brouillard. “RBC transfusions in paroxysmal nocturnal hemoglobinuria.” Arch Intern Med, vol. 137, no. 4, Apr. 1977, pp. 536–38.
Gockerman JP, Brouillard RP. RBC transfusions in paroxysmal nocturnal hemoglobinuria. Arch Intern Med. 1977 Apr;137(4):536–538.
Published In
Arch Intern Med
ISSN
0003-9926
Publication Date
April 1977
Volume
137
Issue
4
Start / End Page
536 / 538
Location
United States
Related Subject Headings
- Vascular Surgical Procedures
- Middle Aged
- Male
- Humans
- Hemolysis
- Hemoglobinuria, Paroxysmal
- General & Internal Medicine
- Erythropoiesis
- Erythrocyte Transfusion
- Erythrocyte Membrane