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RBC transfusions in paroxysmal nocturnal hemoglobinuria.

Publication ,  Journal Article
Gockerman, JP; Brouillard, RP
Published in: Arch Intern Med
April 1977

Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCS, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.

Duke Scholars

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

April 1977

Volume

137

Issue

4

Start / End Page

536 / 538

Location

United States

Related Subject Headings

  • Vascular Surgical Procedures
  • Middle Aged
  • Male
  • Humans
  • Hemolysis
  • Hemoglobinuria, Paroxysmal
  • General & Internal Medicine
  • Erythropoiesis
  • Erythrocyte Transfusion
  • Erythrocyte Membrane
 

Citation

APA
Chicago
ICMJE
MLA
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Gockerman, J. P., & Brouillard, R. P. (1977). RBC transfusions in paroxysmal nocturnal hemoglobinuria. Arch Intern Med, 137(4), 536–538.
Gockerman, J. P., and R. P. Brouillard. “RBC transfusions in paroxysmal nocturnal hemoglobinuria.Arch Intern Med 137, no. 4 (April 1977): 536–38.
Gockerman JP, Brouillard RP. RBC transfusions in paroxysmal nocturnal hemoglobinuria. Arch Intern Med. 1977 Apr;137(4):536–8.
Gockerman, J. P., and R. P. Brouillard. “RBC transfusions in paroxysmal nocturnal hemoglobinuria.Arch Intern Med, vol. 137, no. 4, Apr. 1977, pp. 536–38.
Gockerman JP, Brouillard RP. RBC transfusions in paroxysmal nocturnal hemoglobinuria. Arch Intern Med. 1977 Apr;137(4):536–538.

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

April 1977

Volume

137

Issue

4

Start / End Page

536 / 538

Location

United States

Related Subject Headings

  • Vascular Surgical Procedures
  • Middle Aged
  • Male
  • Humans
  • Hemolysis
  • Hemoglobinuria, Paroxysmal
  • General & Internal Medicine
  • Erythropoiesis
  • Erythrocyte Transfusion
  • Erythrocyte Membrane