RBC transfusions in paroxysmal nocturnal hemoglobinuria.

Journal Article (Journal Article)

Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCS, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.

Full Text

Duke Authors

Cited Authors

  • Gockerman, JP; Brouillard, RP

Published Date

  • April 1, 1977

Published In

Volume / Issue

  • 137 / 4

Start / End Page

  • 536 - 538

PubMed ID

  • 849085

International Standard Serial Number (ISSN)

  • 0003-9926


  • eng

Conference Location

  • United States