Extended survival time following pseudorabies virus injection labels the suprapontine neural network controlling the bladder and urethra in the rat.

Published

Journal Article

The central neurons that are involved in control of the urinary bladder and proximal urethra in adult male rats were identified by retrograde transport of the viral transneural tracer pseudorabies virus (PRV, Bartha strain). At 5 days post-injection, PRV-infected neurons were found in suprapontine central nervous system nuclei including ventrolateral periaqueductal gray, magnocellular division of the red nucleus, lateral hypothalamus and paraventricular nucleus, retrochiasmic region and suprachiasmatic nucleus. At days 6 and 7 PRV-infected neurons were observed in the amygdala, lateral septal nucleus, hippocampus, and frontal motor, piriform, and perirhinal cortices. These results identify the supraspinal neural networks that are involved in control of the lower urinary tract, and demonstrate the utility of long survival times to label higher-order neurons with PRV.

Full Text

Duke Authors

Cited Authors

  • Grill, WM; Erokwu, BO; Hadziefendic, S; Haxhiu, MA

Published Date

  • July 1999

Published In

Volume / Issue

  • 270 / 2

Start / End Page

  • 63 - 66

PubMed ID

  • 10462098

Pubmed Central ID

  • 10462098

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(99)00462-0

Language

  • eng