Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry


Journal Article

The Fourier transform ion cyclotron resonance mass spectrometry remeasurement experiment is demonstrated and evaluated under high resolution conditions. Signal-to-noise enhancement is observed for isotopically resolved bovine insulin peaks at a resolution of ∼ 31,000 (full width at half height). The experiment is sensitive to spacecharge effects and resultant changes in scan-to-scan signal-to-noise and resolution. Coulombic repulsion in the ion cloud during the high resolution remeasurement experiment can cause the cyclotron frequency to shift through the duration of the experiment, which results in broadened peak shapes when individual remeasurement spectra are coadded. By either reducing the number of ions in the cell or allowing the ion cloud to diffuse during the lifetime of the experiment, high resolution remeasurement spectra can be coadded without peak broadening or degradation of signal-to-noise ratio. © 1995 American Society for Mass Spectrometry.

Full Text

Duke Authors

Cited Authors

  • Campbell, VL; Guan, Z; Laude, DA

Published Date

  • January 1, 1995

Published In

Volume / Issue

  • 6 / 7

Start / End Page

  • 564 - 570

Electronic International Standard Serial Number (EISSN)

  • 1879-1123

International Standard Serial Number (ISSN)

  • 1044-0305

Digital Object Identifier (DOI)

  • 10.1016/1044-0305(95)00230-B

Citation Source

  • Scopus