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Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry

Publication ,  Journal Article
Campbell, VL; Guan, Z; Laude, DA
Published in: Journal of the American Society for Mass Spectrometry
January 1, 1995

The Fourier transform ion cyclotron resonance mass spectrometry remeasurement experiment is demonstrated and evaluated under high resolution conditions. Signal-to-noise enhancement is observed for isotopically resolved bovine insulin peaks at a resolution of ∼ 31,000 (full width at half height). The experiment is sensitive to spacecharge effects and resultant changes in scan-to-scan signal-to-noise and resolution. Coulombic repulsion in the ion cloud during the high resolution remeasurement experiment can cause the cyclotron frequency to shift through the duration of the experiment, which results in broadened peak shapes when individual remeasurement spectra are coadded. By either reducing the number of ions in the cell or allowing the ion cloud to diffuse during the lifetime of the experiment, high resolution remeasurement spectra can be coadded without peak broadening or degradation of signal-to-noise ratio. © 1995 American Society for Mass Spectrometry.

Duke Scholars

Published In

Journal of the American Society for Mass Spectrometry

DOI

EISSN

1879-1123

ISSN

1044-0305

Publication Date

January 1, 1995

Volume

6

Issue

7

Start / End Page

564 / 570

Related Subject Headings

  • Analytical Chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
  • 0301 Analytical Chemistry
 

Citation

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ICMJE
MLA
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Campbell, V. L., Guan, Z., & Laude, D. A. (1995). Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry, 6(7), 564–570. https://doi.org/10.1016/1044-0305(95)00230-B
Campbell, V. L., Z. Guan, and D. A. Laude. “Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry.” Journal of the American Society for Mass Spectrometry 6, no. 7 (January 1, 1995): 564–70. https://doi.org/10.1016/1044-0305(95)00230-B.
Campbell VL, Guan Z, Laude DA. Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry. 1995 Jan 1;6(7):564–70.
Campbell, V. L., et al. “Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry.” Journal of the American Society for Mass Spectrometry, vol. 6, no. 7, Jan. 1995, pp. 564–70. Scopus, doi:10.1016/1044-0305(95)00230-B.
Campbell VL, Guan Z, Laude DA. Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry. 1995 Jan 1;6(7):564–570.
Journal cover image

Published In

Journal of the American Society for Mass Spectrometry

DOI

EISSN

1879-1123

ISSN

1044-0305

Publication Date

January 1, 1995

Volume

6

Issue

7

Start / End Page

564 / 570

Related Subject Headings

  • Analytical Chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
  • 0301 Analytical Chemistry