Skip to main content

Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB.

Publication ,  Journal Article
Klaunig, JE; Lipsky, MM; Trump, BF; Hinton, DE
Published in: Journal of environmental pathology and toxicology
March 1979

The response of the channel catfish liver to subacute exposure of polychlorinated biphenyls was evaluated using electron microscopic and biochemical techniques. After 21 days, treated fish displayed elevated microsomal enzyme activities. Morphologically, the liver produced several patterns of alteration involving the endoplasmic reticulum (ER). Structural alterations included an increase in tubular smooth ER, production of parallel stacks of smooth ER showing continuity with rough ER, and membranous whorls. Biochemical and morphologic findings were correlated in exposed livers, and the relationship of these findings to similar studies in other species of fish is discussed.

Duke Scholars

Published In

Journal of environmental pathology and toxicology

ISSN

0146-4779

Publication Date

March 1979

Volume

2

Issue

4

Start / End Page

953 / 963

Related Subject Headings

  • Time Factors
  • Polychlorinated Biphenyls
  • Mixed Function Oxygenases
  • Male
  • Liver
  • Fishes
  • Female
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Klaunig, J. E., Lipsky, M. M., Trump, B. F., & Hinton, D. E. (1979). Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB. Journal of Environmental Pathology and Toxicology, 2(4), 953–963.
Klaunig, J. E., M. M. Lipsky, B. F. Trump, and D. E. Hinton. “Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB.Journal of Environmental Pathology and Toxicology 2, no. 4 (March 1979): 953–63.
Klaunig JE, Lipsky MM, Trump BF, Hinton DE. Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB. Journal of environmental pathology and toxicology. 1979 Mar;2(4):953–63.
Klaunig, J. E., et al. “Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB.Journal of Environmental Pathology and Toxicology, vol. 2, no. 4, Mar. 1979, pp. 953–63.
Klaunig JE, Lipsky MM, Trump BF, Hinton DE. Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB. Journal of environmental pathology and toxicology. 1979 Mar;2(4):953–963.

Published In

Journal of environmental pathology and toxicology

ISSN

0146-4779

Publication Date

March 1979

Volume

2

Issue

4

Start / End Page

953 / 963

Related Subject Headings

  • Time Factors
  • Polychlorinated Biphenyls
  • Mixed Function Oxygenases
  • Male
  • Liver
  • Fishes
  • Female
  • Animals