Comparison of acute response to polychlorinated biphenyl in liver of rat and channel catfish: a biochemical and morphological study.

Journal Article (Journal Article)

The acute response of liver of channel catfish and rat to polychlorinated biphenyl was compared on a structural and functional basis. Both the rat and the fish had elevated microsomal enzyme activities. However, in the rat the response was quantitatively greater in all respects. Morphologically, rats responded with lipid accumulation and marked increases in smooth endoplasmic reticulum. Fish liver showed lipid accumulation and increased profiles of rough endoplasmic reticulum with alterations in arrangement that appeared as vesicles and parallel cisternae. Minimal changes were seen in smooth endoplasmic reticulum, which appeared to be increased as discrete foci.

Full Text

Duke Authors

Cited Authors

  • Lipsky, MM; Klaunig, JE

Published Date

  • January 1, 1978

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 107 - 121

PubMed ID

  • 416227

International Standard Serial Number (ISSN)

  • 0098-4108

Digital Object Identifier (DOI)

  • 10.1080/15287397809529648


  • eng