The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.
Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved "housekeeping" genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2.
Duke Scholars
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Recombination, Genetic
- Proto-Oncogenes
- Proto-Oncogene Proteins c-abl
- Proto-Oncogene Proteins
- Proto-Oncogene Mas
- Polymorphism, Restriction Fragment Length
- Muridae
- Mice, Inbred C57BL
- Mice
- Male
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Recombination, Genetic
- Proto-Oncogenes
- Proto-Oncogene Proteins c-abl
- Proto-Oncogene Proteins
- Proto-Oncogene Mas
- Polymorphism, Restriction Fragment Length
- Muridae
- Mice, Inbred C57BL
- Mice
- Male