Scholars@Duke publication: Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

Publication , Journal Article

Dickinson, ME; Kobrin, MS; Silan, CM; Kingsley, DM; Justice, MJ; Miller, DA; Ceci, JD; Lock, LF; Lee, A; Buchberg, AM

Published in: Genomics

March 1990

Chromosomal locations have been assigned to seven members of the TGF-beta superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-beta superfamily map to eight different chromosomes, indicating that the TGF-beta family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-beta-related genes.

Duke Scholars

Author Brigid L. M. Hogan Cell Biology

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Published In

Genomics

DOI

10.1016/0888-7543(90)90480-i

ISSN

0888-7543

Publication Date

March 1990

Volume

Issue

Start / End Page

505 / 520

Location

United States

Related Subject Headings

Transforming Growth Factors
Species Specificity
Sequence Homology, Nucleic Acid
Polymorphism, Restriction Fragment Length
Muridae
Multigene Family
Molecular Sequence Data
Mice, Mutant Strains
Mice, Inbred Strains
Mice

Citation

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Dickinson, M. E., Kobrin, M. S., Silan, C. M., Kingsley, D. M., Justice, M. J., Miller, D. A., … Buchberg, A. M. (1990). Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics, 6(3), 505–520. https://doi.org/10.1016/0888-7543(90)90480-i

Dickinson, M. E., M. S. Kobrin, C. M. Silan, D. M. Kingsley, M. J. Justice, D. A. Miller, J. D. Ceci, L. F. Lock, A. Lee, and A. M. Buchberg. “Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.” Genomics 6, no. 3 (March 1990): 505–20. https://doi.org/10.1016/0888-7543(90)90480-i.

Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, et al. Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics. 1990 Mar;6(3):505–20.

Dickinson, M. E., et al. “Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.” Genomics, vol. 6, no. 3, Mar. 1990, pp. 505–20. Pubmed, doi:10.1016/0888-7543(90)90480-i.

Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM. Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics. 1990 Mar;6(3):505–520.

Published In

Genomics

DOI

10.1016/0888-7543(90)90480-i

ISSN

0888-7543

Publication Date

March 1990

Volume

Issue

Start / End Page

505 / 520

Location

United States

Related Subject Headings

Transforming Growth Factors
Species Specificity
Sequence Homology, Nucleic Acid
Polymorphism, Restriction Fragment Length
Muridae
Multigene Family
Molecular Sequence Data
Mice, Mutant Strains
Mice, Inbred Strains
Mice