Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

Published

Journal Article

Chromosomal locations have been assigned to seven members of the TGF-beta superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-beta superfamily map to eight different chromosomes, indicating that the TGF-beta family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-beta-related genes.

Full Text

Duke Authors

Cited Authors

  • Dickinson, ME; Kobrin, MS; Silan, CM; Kingsley, DM; Justice, MJ; Miller, DA; Ceci, JD; Lock, LF; Lee, A; Buchberg, AM

Published Date

  • March 1, 1990

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 505 - 520

PubMed ID

  • 1970330

Pubmed Central ID

  • 1970330

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(90)90480-i

Language

  • eng

Conference Location

  • United States