A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.

Published

Journal Article

The homoeo box sequence of Drosophila is an element located in several genes that regulate segmentation and segment identity; it has homologues in the genomes of vertebrate species and a number of homoeo box-containing recombinant DNA clones have been isolated from Xenopus, man and mouse. In the present study we have isolated from a library of murine DNA a recombinant lambda clone (H24.1) which contains a sequence closely homologous to the homoeo box within the Drosophila Antennapedia (Antp) gene. The protein sequence of the homoeo domain is identical to that encoded by Hu-1, one of a the pair of closely linked homoeo boxes in the human genome. We have used a sensitive RNase protection assay to examine transcription of the H24.1 gene during mouse development, and in adult tissues. We report that the gene is transcribed from as early as 7.5 days post coitum (p.c.), with maximum expression at days 11.5 and 12.5 p.c. The transcript is enriched in embryonic spinal cord and brain at day 12.5 p.c., and in adult kidney.

Full Text

Duke Authors

Cited Authors

  • Jackson, IJ; Schofield, P; Hogan, B

Published Date

  • October 24, 1985

Published In

Volume / Issue

  • 317 / 6039

Start / End Page

  • 745 - 748

PubMed ID

  • 4058581

Pubmed Central ID

  • 4058581

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/317745a0

Language

  • eng

Conference Location

  • England