Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation.
Journal Article (Journal Article)
The present study was designed to examine the induction of c-fos mRNA and Fos-like protein in the rostral medulla of awake rats following electroacupuncture (EA) stimulation, using in situ hybridization and immunohistochemical method. Rats were subjected to EA stimulation (100 Hz, 1-2-3 mA) for 30 min by inserting two needles into acupoints Zusanli (S36) and Sanyingjiao (Sp6) of each hind leg. Animals were sacrificed 1h and 2h after EA for in situ hybridization and immunohistochemical study, respectively. c-fos mRNA or Fos-like-immunoreactivity (FLI) neurons were densely distributed in the rostral ventromedial medulla (RVM), including raphe magnus nucleus, gigantocellular reticular nucleus, gigantocellular reticular nucleus alpha, as well as intermediate reticular nucleus. Neurons in the solitary tract nucleus also showed c-fos expression. The results suggest that the RVM may be an important region for mediating EA effect.
Full Text
Duke Authors
Cited Authors
- Ji, RR; Zhang, ZW; Zhou, Y; Zhang, Q; Han, JS
Published Date
- October 1993
Published In
Volume / Issue
- 72 / 3-4
Start / End Page
- 183 - 191
PubMed ID
- 8138374
International Standard Serial Number (ISSN)
- 0020-7454
Digital Object Identifier (DOI)
- 10.3109/00207459309024107
Language
- eng
Conference Location
- England