Scholars@Duke publication: Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation.

Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation.

Publication , Journal Article

Ji, RR; Zhang, ZW; Zhou, Y; Zhang, Q; Han, JS

Published in: Int J Neurosci

October 1993

The present study was designed to examine the induction of c-fos mRNA and Fos-like protein in the rostral medulla of awake rats following electroacupuncture (EA) stimulation, using in situ hybridization and immunohistochemical method. Rats were subjected to EA stimulation (100 Hz, 1-2-3 mA) for 30 min by inserting two needles into acupoints Zusanli (S36) and Sanyingjiao (Sp6) of each hind leg. Animals were sacrificed 1h and 2h after EA for in situ hybridization and immunohistochemical study, respectively. c-fos mRNA or Fos-like-immunoreactivity (FLI) neurons were densely distributed in the rostral ventromedial medulla (RVM), including raphe magnus nucleus, gigantocellular reticular nucleus, gigantocellular reticular nucleus alpha, as well as intermediate reticular nucleus. Neurons in the solitary tract nucleus also showed c-fos expression. The results suggest that the RVM may be an important region for mediating EA effect.

Duke Scholars

Author Ru-Rong Ji Anesthesiology

Published In

Int J Neurosci

DOI

10.3109/00207459309024107

ISSN

0020-7454

Publication Date

October 1993

Volume

Issue

3-4

Start / End Page

183 / 191

Location

England

Related Subject Headings

Transcutaneous Electric Nerve Stimulation
Spinal Cord
Rats, Wistar
Rats
Pain
Neurology & Neurosurgery
Medulla Oblongata
In Situ Hybridization
Hindlimb
Genes, fos

Citation

APA

Chicago

ICMJE

MLA

NLM

Ji, R. R., Zhang, Z. W., Zhou, Y., Zhang, Q., & Han, J. S. (1993). Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation. Int J Neurosci, 72(3–4), 183–191. https://doi.org/10.3109/00207459309024107

Ji, R. R., Z. W. Zhang, Y. Zhou, Q. Zhang, and J. S. Han. “Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation.” Int J Neurosci 72, no. 3–4 (October 1993): 183–91. https://doi.org/10.3109/00207459309024107.

Ji RR, Zhang ZW, Zhou Y, Zhang Q, Han JS. Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation. Int J Neurosci. 1993 Oct;72(3–4):183–91.

Ji, R. R., et al. “Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation.” Int J Neurosci, vol. 72, no. 3–4, Oct. 1993, pp. 183–91. Pubmed, doi:10.3109/00207459309024107.

Ji RR, Zhang ZW, Zhou Y, Zhang Q, Han JS. Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation. Int J Neurosci. 1993 Oct;72(3–4):183–191.