The role of hematopoietic growth factors and oncogenes in leukemogenesis.

Journal Article (Journal Article;Review)

Understanding of the roles and molecular mechanisms of hematopoietic growth factors has increased greatly in recent years. This past decade has also brought us tantalizingly close to linking a group of genes normally involved in the regulation of growth and differentiation--the cellular proto-oncogenes--to the process of malignant transformation. In this article, we review the known actions of hematopoietic growth factors in normal hematopoiesis and in hematologic malignancies. We then discuss current concepts of the roles of proto-oncogenes in normal cells and their potential involvement in leukemogenic events. A merging of these concepts with classical hypotheses of multistage carcinogenesis is emphasized.

Full Text

Duke Authors

Cited Authors

  • Kastan, MB; Strauss, LC; Civin, CI

Published Date

  • 1989

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 249 - 267

PubMed ID

  • 2675658

International Standard Serial Number (ISSN)

  • 0192-8562


  • eng

Conference Location

  • United States