The centrosome in human genetic disease.


Journal Article (Review)

The centrosome is an indispensable component of the cell-cycle machinery of eukaryotic cells, and the perturbation of core centrosomal or centrosome-associated proteins is linked to cell-cycle misregulation and cancer. Recent work has expanded our understanding of the functional complexity and importance of this organelle. The centrosomal localization of proteins that are involved in human genetic disease, and the identification of novel centrosome-associated proteins, has shown that numerous, seemingly unrelated, cellular processes can be perturbed by centrosomal dysfunction. Here, we review the mechanistic relationship between human disease phenotypes and the function of the centrosome, and describe some of the newly-appreciated functions of this organelle in animal cells.

Full Text

Cited Authors

  • Badano, JL; Teslovich, TM; Katsanis, N

Published Date

  • March 2005

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 194 - 205

PubMed ID

  • 15738963

Pubmed Central ID

  • 15738963

International Standard Serial Number (ISSN)

  • 1471-0056

Digital Object Identifier (DOI)

  • 10.1038/nrg1557


  • eng

Conference Location

  • England