Characteristics of very poor outcome schizophrenia.


Journal Article

The authors compared 21 "Kraepelinian" schizophrenic patients who had been ill and dependent on others for the past 5 years with 76 chronic schizophrenic patients in remission or with exacerbations requiring hospitalization. The Kraepelinian patients met the criteria for schizophrenia by more diagnostic systems than the exacerbated patients, were less responsive to haloperidol, had more severe negative symptoms, and had similarly severe positive symptoms. They had cerebral ventricles that were more asymmetrical and a greater family history of schizophrenia spectrum disorders than the other chronic patients. These data suggest that patients with 5 years of illness and complete dependency on others may represent a subgroup of schizophrenia.

Full Text

Duke Authors

Cited Authors

  • Keefe, RS; Mohs, RC; Losonczy, MF; Davidson, M; Silverman, JM; Kendler, KS; Horvath, TB; Nora, R; Davis, KL

Published Date

  • July 1, 1987

Published In

Volume / Issue

  • 144 / 7

Start / End Page

  • 889 - 895

PubMed ID

  • 3605400

Pubmed Central ID

  • 3605400

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.144.7.889


  • eng

Conference Location

  • United States