Nucleotide sequence and host La protein interactions of rabies virus leader RNA.

Journal Article (Journal Article)

Rabies virus leader RNA was detected in infected BHK-21 cell extracts by hybridization to end-labeled genomic RNA. Similar to the leader RNA of vesicular stomatitis virus, the leader RNA of rabies virus was also found to be associated with the La protein by specific immunoprecipitation with antisera from lupus patients. The 3' end of the genomic RNA of rabies virus was sequenced, and the size and termination site of leader RNA were determined. In addition, extension of the sequence into the nucleocapsid gene of rabies virus showed an open reading frame for at least 37 amino acid residues. Sequence relationships between rabies virus and vesicular stomatitis virus leader genes and the possible involvement of the La protein in rhabdovirus biology are discussed.

Full Text

Duke Authors

Cited Authors

  • Kurilla, MG; Cabradilla, CD; Holloway, BP; Keene, JD

Published Date

  • June 1984

Published In

Volume / Issue

  • 50 / 3

Start / End Page

  • 773 - 778

PubMed ID

  • 6328006

Pubmed Central ID

  • PMC255736

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.50.3.773-778.1984


  • eng

Conference Location

  • United States