Association between the 7 S RNA and the lupus La protein varies among cell types

Journal Article

The La antigen recognized by certain lupus erythematosus autoantibodies was found to be predominantly associated with 7 S RNA in baby hamster kidney cells and human Raji cells, but not in HeLa cells where mainly the 7-2 RNA was associated with the La protein. In mouse myeloma cells (MPC-11) and mouse lymphoma cells (WEHI) that secrete immunoglobulins, equal amounts of 7 S and 7-2 RNAs were present in anti-La immunoprecipitates. The highly conserved 7 S RNA is a component of the signal recognition particle involved in protein secretion, and its association with the La antigen appeared to be cell-type specific. Thus, it is possible that the La-7 S RNA association correlates with the abundance of 7 S RNA or with the secretory activity of the cell type.

Duke Authors

Cited Authors

  • Chambers, JC; Kurilla, MG; Keene, JD

Published Date

  • 1983

Published In

  • Journal of Biological Chemistry

Volume / Issue

  • 258 / 19

Start / End Page

  • 11438 - 11441