Priority of the anti-idiotypic response after antigen administration: artefact or intriguing network mechanism?

Journal Article (Journal Article)

Immunization triggers at least two speck responses measurable at cellular and humoral levels: the antigen-driven proliferation of idiotype-bearing (idt+) cells; and an autochthonous anti-idt response'. As the expansion of the idt* clone(s) is presumed to provide the activating stimulus for the complementary response, one expects the proliferation of anti-idt clones to follow the idt response at an interval equivalent to the time required for ~pmphocyte activation. However, there have been several reports of an autochthonous anti-idt response preceding the expansion of antigen-driven idt' clone(s). In this brief commentary, we examine these reports and offer some suggestions that may resolve this apparent paradox. © 1984.

Full Text

Duke Authors

Cited Authors

  • Cerny, J; Kelsoe, G

Published Date

  • January 1, 1984

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 61 - 63

International Standard Serial Number (ISSN)

  • 0167-5699

Digital Object Identifier (DOI)

  • 10.1016/0167-5699(84)90165-8

Citation Source

  • Scopus