Use of antidepressants in medically ill older patients.


Journal Article (Review)

Major depression is common in older medical patients, and it can exert a deleterious effect on the treatment, course, and outcome of physical illnesses. Tricyclic or tetracyclic antidepressants (TCAs) and psychosocial interventions often play a role in the treatment of depressed medically ill patients, but well-founded doubts about the efficacy and the safety of TCAs in older, frail medical patients have developed. Based on a review of current knowledge about antidepressant use in these patients, the authors recommend the cautious use of TCAs in medically ill older patients until more data are available.

Full Text

Duke Authors

Cited Authors

  • Koenig, HG; Breitner, JC

Published Date

  • 1990

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 22 - 32

PubMed ID

  • 2405449

Pubmed Central ID

  • 2405449

International Standard Serial Number (ISSN)

  • 0033-3182

Digital Object Identifier (DOI)

  • 10.1016/S0033-3182(90)72213-X


  • eng

Conference Location

  • England