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Ontogeny of rat hepatic adrenoceptors.

Publication ,  Journal Article
McMillian, MK; Schanberg, SM; Kuhn, CM
Published in: J Pharmacol Exp Ther
October 1983

Hepatic alpha-1, alpha-2 and beta-2 adrenoceptors were characterized during development of the rat through Scatchard analysis of [3H]prazosin, [3H]rauwolscine and [125I]pindolol binding to liver membrane preparations. Major changes in adrenoceptor numbers occur shortly before birth at weaning. The fetal rat liver is characterized by a large number of alpha-2 adrenoceptors, which falls 10-fold by birth. The number of hepatic beta-2 adrenoceptors decreases gradually during development, and is lower at all times than the number of alpha-1 and alpha-2 adrenoceptors. The developmental profile of the hepatic alpha-1 adrenoceptor is biphasic: there is a 2 to 3-fold fall in alpha-1 adrenoceptor number at birth and a 3- to 5-fold rise at weaning. While absolute numbers of alpha-1 and beta-2 adrenoceptors do not correlate precisely with reported actions of epinephrine and norepinephrine on hepatic metabolism during ontogeny, the increasing ratio of alpha-1/beta-2 hepatic adrenoceptors may contribute to the conversion from predominantly beta effects of catecholamines reported in fetal and suckling rat liver to the predominantly alpha-1 effects that are well documented in the adult male rat.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

October 1983

Volume

227

Issue

1

Start / End Page

181 / 186

Location

United States

Related Subject Headings

  • Tritium
  • Secologanin Tryptamine Alkaloids
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Rats, Inbred Strains
  • Rats
  • Prazosin
  • Pindolol
  • Pharmacology & Pharmacy
 

Citation

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MLA
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McMillian, M. K., Schanberg, S. M., & Kuhn, C. M. (1983). Ontogeny of rat hepatic adrenoceptors. J Pharmacol Exp Ther, 227(1), 181–186.
McMillian, M. K., S. M. Schanberg, and C. M. Kuhn. “Ontogeny of rat hepatic adrenoceptors.J Pharmacol Exp Ther 227, no. 1 (October 1983): 181–86.
McMillian MK, Schanberg SM, Kuhn CM. Ontogeny of rat hepatic adrenoceptors. J Pharmacol Exp Ther. 1983 Oct;227(1):181–6.
McMillian, M. K., et al. “Ontogeny of rat hepatic adrenoceptors.J Pharmacol Exp Ther, vol. 227, no. 1, Oct. 1983, pp. 181–86.
McMillian MK, Schanberg SM, Kuhn CM. Ontogeny of rat hepatic adrenoceptors. J Pharmacol Exp Ther. 1983 Oct;227(1):181–186.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

October 1983

Volume

227

Issue

1

Start / End Page

181 / 186

Location

United States

Related Subject Headings

  • Tritium
  • Secologanin Tryptamine Alkaloids
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic
  • Rats, Inbred Strains
  • Rats
  • Prazosin
  • Pindolol
  • Pharmacology & Pharmacy