Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat.

Published

Journal Article

The effect of ovine growth hormone (GH) on kidney ornithine decarboxylase (ODC) was studied in newborn, preweanling and young adult rats. Basal kidney ODC activity was very low from 4 to 22 days after birth but rose 20-fold by day 25; it remained elevated through day 45. GH failed to stimulate ODC in the first two weeks after birth. GH did however stimulate ODC markedly from 20 through 45 days. Kidney ODC was stimulated in the neonate by vasopressin and by isoproterenol, but not by angiotensin II. Liver ODC remained relatively low and stable during development, and was responsive to GH at all ages studied. We conclude that a) the pattern of development of basal kidney ODC appears to be unique to this tissue and may be related to the postnatal maturation of renal morphology and/or function, b) neonatal kidney ODC is unresponsive to certain hormones but is not completely refractory to stimulation. These findings may have implications for the role of hormones in the maturation of the kidney and in the regulation of early renal function.

Full Text

Duke Authors

Cited Authors

  • Grignolo, A; Kuhn, CM; Schanberg, SM

Published In

Volume / Issue

  • 30 / 4

Start / End Page

  • 383 - 390

PubMed ID

  • 7070214

Pubmed Central ID

  • 7070214

International Standard Serial Number (ISSN)

  • 0024-3205

Language

  • eng

Conference Location

  • Netherlands