Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias.

Published

Journal Article

Paroxysmal atrial tachycardia may be useful as a model for designing clinical trials of paroxysmal tachycardia. Individual occurrences of paroxysmal atrial tachycardia are clinically independent events, and the time periods between events follow an exponential probability distribution; i.e. paroxysmal atrial tachycardia behaves like a Poisson process. We propose that treatment of paroxysmal atrial tachycardia can be studied efficiently using a clinical trial with a two period cross-over design in which placebo and investigational therapy are delivered in random order. A screening phase, dose ranging phase, and both limbs of a cross-over plane can be completed in 180 days or less in each patient.

Full Text

Duke Authors

Cited Authors

  • Pritchett, EL; Lee, KL

Published Date

  • 1988

Published In

Volume / Issue

  • 41 / 9

Start / End Page

  • 851 - 858

PubMed ID

  • 3183691

Pubmed Central ID

  • 3183691

International Standard Serial Number (ISSN)

  • 0895-4356

Language

  • eng

Conference Location

  • United States