Effects of long-term estrogen replacement therapy. I. Metabolic effects.

Journal Article (Journal Article)

Two groups of hypoestrogenic women are analyzed by retrospective comparisons. Patients were observed by a single group of physicians for at least five years; 301 patients were treated with replacement estrogen and 309 patients were untreated. Incidence figures for various metabolic diseases present at entry and both during and after estrogen therapy were compared by the usual statistical analysis and by statistical adjustments for certain group differences (Mantel-Haenszel statistic). The long-term administration of estrogen to these relatively young women with hypoestrogenism was associated with significantly lower rates of development of cardiovascular disease, hypertension, osteoporosis, and fractures. Detrimental effects were a higher rate of abnormal uterine bleeding and an increase in the likelihood of developing adenocarcinoma of the endometrium. Effects of estrogen preparation, dosage, method of therapy, duration of therapy, and the addition of synthetic progestins are presented.

Full Text

Duke Authors

Cited Authors

  • Hammond, CB; Jelovsek, FR; Lee, KL; Creasman, WT; Parker, RT

Published Date

  • March 1, 1979

Published In

Volume / Issue

  • 133 / 5

Start / End Page

  • 525 - 536

PubMed ID

  • 443293

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/0002-9378(79)90288-6


  • eng

Conference Location

  • United States