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Opposite effects of a D1 and a D2 agonist on oral movements in rats.

Publication ,  Journal Article
Johansson, P; Levin, E; Gunne, L; Ellison, G
Published in: Eur J Pharmacol
January 28, 1987

Oral movements in rats administered one of three doses of either a D1 agonist (SK&F 38393) or a D2 agonist (LY171555) were observed via closed-circuit television and simultaneously recorded using a computerized video analysis system which measured the distance between two fluorescent dots painted above and below the rat's mouth. The D1 agonist SK&F 38393 induced a dose-dependent increase in tremorous oral movements, tongue protrusions, and, at the highest dose, increased repetitive chewing movements. Conversely, the D2 agonist LY171555 produced an inhibition or oral activity at all dose levels. At the lowest dose tested this appeared to reflect a non-specific decrease in activity, for there was an inhibition of all categories of behavior measured, as well as of all amplitudes of computer-scored movements and slow, sluggish movements were recorded. But higher doses of LY171555 induced hyperactivity and stereotyped, repetitive head movements whereas chewing movements, tremorous oral movements, and tongue protrusions were still decreased. D1 and D2 dopamine receptors appear to have opposite effects on oral movements.

Duke Scholars

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

January 28, 1987

Volume

134

Issue

1

Start / End Page

83 / 88

Location

Netherlands

Related Subject Headings

  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Quinpirole
  • Pharmacology & Pharmacy
  • Movement
  • Mouth
  • Female
  • Ergolines
  • Dyskinesia, Drug-Induced
 

Citation

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Johansson, P., Levin, E., Gunne, L., & Ellison, G. (1987). Opposite effects of a D1 and a D2 agonist on oral movements in rats. Eur J Pharmacol, 134(1), 83–88. https://doi.org/10.1016/0014-2999(87)90134-8
Johansson, P., E. Levin, L. Gunne, and G. Ellison. “Opposite effects of a D1 and a D2 agonist on oral movements in rats.Eur J Pharmacol 134, no. 1 (January 28, 1987): 83–88. https://doi.org/10.1016/0014-2999(87)90134-8.
Johansson P, Levin E, Gunne L, Ellison G. Opposite effects of a D1 and a D2 agonist on oral movements in rats. Eur J Pharmacol. 1987 Jan 28;134(1):83–8.
Johansson, P., et al. “Opposite effects of a D1 and a D2 agonist on oral movements in rats.Eur J Pharmacol, vol. 134, no. 1, Jan. 1987, pp. 83–88. Pubmed, doi:10.1016/0014-2999(87)90134-8.
Johansson P, Levin E, Gunne L, Ellison G. Opposite effects of a D1 and a D2 agonist on oral movements in rats. Eur J Pharmacol. 1987 Jan 28;134(1):83–88.
Journal cover image

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

January 28, 1987

Volume

134

Issue

1

Start / End Page

83 / 88

Location

Netherlands

Related Subject Headings

  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Quinpirole
  • Pharmacology & Pharmacy
  • Movement
  • Mouth
  • Female
  • Ergolines
  • Dyskinesia, Drug-Induced