Higher density of serotonin-1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats

Journal Article

Saturable [3H]-80HDPAT binding to 5HT-1A receptors in membranes prepared from hippocampus and frontal cerebral cortex of alcohol-preferring P rats and of alcohol-nonpreferring NP rats has been compared. The Bmax values or densities of recognition sites for 5HT-1A receptors in both brain areas of the P rats are 39 and 131 percent, respectively, higher than those in the NP rats. The corresponding KD values are 38 and 44 percent lower in the P rats than in the NP rats, indicating higher affinities of the recognition sites for the 5HT-1A receptors in hippocampus and cerebral cortex of the P rats. These findings indicate either an enrichment of 5HT-1A receptor density during selective breeding for alcohol preference or an upregulation of 5HT-1A receptors developed as an adaptation to lower presynaptic concentrations of 5HT found in these brain areas of P rats as compared with the NP rats. © 1990.

Full Text

Cited Authors

  • Wong, DT; Threlkeld, PG; Lumeng, L; Li, TK

Published Date

  • 1990

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 231 - 235

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(90)90109-5