Serotonergic and adrenergic receptors in alcohol-preferring and non-preferring rats
Serotonergic and adrenergic receptors in brain areas of the alcohol-preferring P and alcohol-nonpreferring NP rats were compared by radioligand-binding assays. Binding of3H-serotonin (3H-5HT) to 5HT-1 receptors in membranes of cerebral cortex and hippocampus was significantly higher in density (B max values) and affinity (Kd values) in the P than in the NP rats, whereas B max values in membranes from the brain stem of the P rats were lower than those of the NP rats. No significant difference between the P and NP lines was observed when the binding of3H-ketanserin to 5HT-2 receptors and of3H-WB4101,3H-clonidine and3H-dihydoalprenolol to α-1, α-2 and β-adrenergic receptors was compared. The increase of3H-5HT binding probably indicates up-regulation or supersensitivity of 5HT-1 receptors as a compensatory mechanism to the lower levels of 5HT in brain areas of the P rats (Murphy, et al., 1982). © 1988 Springer Verlag.
Wong, DT; Lumeng, L; Threlkeld, PG; Reid, LR; Li, TK
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